Clinical outcomes

Psychometric evidence for clinical outcome assessments.

I provide psychometric analysis and validation for patient-reported and clinician-reported outcome measures, bringing measurement methods proven in high-stakes testing to the instruments that support clinical endpoints.

Who I work with

  • CROs and outcomes research firms that need senior psychometric capacity
  • Pharmaceutical and biotech sponsors developing or adapting COAs
  • Academic teams developing and validating new instruments

What I do

  • Psychometric analysis plans. The psychometric sections of analysis plans, written before the data arrive.
  • Item and scale analysis. Classical and item response theory (IRT/Rasch) analyses, item reduction, and short-form development.
  • Dimensionality and structure. Exploratory and confirmatory factor analysis, with clear reasoning about which one the evidence calls for.
  • Reliability and validity. Internal consistency, test-retest, construct validity, and known-groups evidence.
  • Measurement invariance and DIF. Evidence that an instrument works the same way across subgroups, languages, and cultures.
  • Validity argument and reporting. Clear write-ups of what the evidence supports, for internal teams, publications, and regulatory dossiers.

Relevant work

  • Co-authored "Fit for purpose and modern validity theory in clinical outcomes assessment" (Quality of Life Research, invited special section)
  • Presented "Current thinking in validity theory" at the DIA Annual Meeting
  • Psychometric development and validation of the Penn Parkinson's Daily Activities Questionnaire and its 15-item short form
  • Measurement model evaluation for the Mini-Mental State Examination (Psychological Assessment)
  • Conducted the exploratory and confirmatory factor analyses developing and validating the Novice Nurse Practitioner Role Transition Scale
  • Consulting Editor, Psychological Assessment

Why a licensure psychometrician?

High-stakes licensure testing is one of the most scrutinized measurement environments there is. Fairness analyses, invariance testing, and validity arguments have to survive legal and public challenge. I bring that standard of evidence to clinical outcome assessment, and I work alongside your outcomes researchers and regulatory team, not in place of them.

Available as a subcontractor or directly to sponsors

For defined analyses or ongoing psychometric support.

Book a 30-minute call